Sertraline

Sertraline is an antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It is thought to work by increasing levels of a chemical called serotonin in the brain [1].

It is used to treat depression, and also conditions such as panic attacks, obsessive compulsive disorder (OCD), post-traumatic stress disorder (PTSD) and social anxiety [1]. It comes as tablets and is available only on prescription [1].

• Sertraline is usually taken once a day, and it can take a few weeks to feel the full benefit [1].
• Side effects such as feeling sick are common early on and often ease within a couple of weeks [1].
• Do not stop taking it suddenly, as this can cause withdrawal effects [1].
• Speak to a doctor if your mood gets worse or you have distressing thoughts [1].

Sertraline can be taken by many adults, and by some children and young people for certain conditions [1]. It may not be suitable, or may need extra care, if you have had an allergic reaction to it, or if you have conditions such as epilepsy, heart problems, bleeding problems, diabetes or glaucoma [1]. Tell your prescriber about your health and any other medicines so they can decide whether it is right for you [1].

Take sertraline as your prescriber tells you and as set out on the label — usually once a day, in the morning or evening, with or without food [1]. The dose is often started low and adjusted over time [1]. If you miss a dose, take the next one at the usual time rather than doubling up [1]. Keep taking it as prescribed, and talk to your doctor before making any changes [1].

Common side effects can include feeling sick, headaches, trouble sleeping, dizziness, a dry mouth and diarrhoea, and these often settle as your body adjusts [1]. Some people notice effects on sex drive [1]. Get urgent medical help for signs of a serious reaction, and speak to a doctor quickly if you have thoughts of harming yourself [1].

Sertraline can interact with a number of medicines, including other antidepressants (especially MAOIs), anti-inflammatory painkillers, blood thinners and the herbal remedy St John's wort [1]. Combining certain medicines can raise the risk of a serious reaction, so tell a pharmacist or doctor what else you take, including over-the-counter products, before starting it [1].

You can report a suspected side effect from sertraline to the MHRA through the Yellow Card scheme, which helps monitor medicine safety in the UK [2]. Seek medical help for any serious reaction as well as reporting it.